Endocrine Abstracts

The defective conversion of testosterone to dihydrotestosterone due to a steroid 5-alpha-reductase 2 deficiency results in a unique form of 46, XY disorder of sexual development (DSD). Dihydrotestosterone is essential for the embryonic differentiation of the external male genitalia and the prostate. Steroid 5-alpha-reductase 2 deficiency is an autosomal recessive disorder in which genetic males have a predominantly female phenotype with female external genitalia but male inter...

Introduction: Medullary thyroid cancer (MTC) TNM classification categorizes lymph nodes (LN) according to their location, but does not consider number and size of LN.Objective: To analyze the relationship between number and size of LN in MCT persistent disease (PD).Material and methods: Retrospective study of patients with MTC followed up in a regional hospital from 1985 to 2015. The main variables (expressed as qualitative in freq...

Although the effect of aging on adipose tissue metabolism have been thoroughly studied for years, changes in the antilipolytic action of insulin in visceral white adipose tissue from aged rats are still not completely understood. By fact, some contradictory data on the inhibition of isoproterenol-induced lipolysis by insulin with aging have been reported. As aging is a significant risk factor for increasing adiposity and the development of obesity, we hypothesized that the inh...

Clinical case: We report the case of a 40-year-old woman, diagnosed with sporadic medullary thyroid carcinoma (MTC) treated with total thyroidectomy, cervical lymph node dissection and chemotherapy. During follow-up, cervical lymph node, lung, breast, bone and subcentimeter cerebellous affectation was observed. She started on Sunitinib, but withdrawal at 6 months due to severe inguinal inverse psoriasis. Then, treatment with vandetanib was started with good response. Tumor mar...

Introduction: Follicular neoplasm (FN) or suspicious for a follicular neoplasm category is established by The Bethesda System for Reporting Thyroid Cytopathology because of the necessity to identify a nodule that might be a follicular carcinoma and triage it for surgical lobectomy. Estimated risk of malignancy for this category is 15–30%.Description of methods: We conducted a retrospective study that included all patients with a follicular neoplasm ...

Introduction: Evaluation of postmenopausal hyperandrogenism may be a challenge for physicians as it is necessary to exclude the presence of the relatively rare but potentially life-threatening underlying tumorous causes. We report the case of a postmenopausal woman who presented with clinical and biochemical hyperandrogenism.Case Report: We present the case of a 65 year-old woman being followed at our clinic because of mild hypothyroidism. At inspection ...

This study was conducted to evaluate the frequency of PCOS in a group of FTM transsexual persons and its relationship between clinical, hormonal and metabolic characteristics.Subjects and Methods: We studied 21 FTM cases, aged 17–37 years, BMI 24.6±5.2. No patient reported previous hormonal treatment or sex re-assignment surgery. PCOS was diagnosed according to the Rotterdam ESHRE/ASRM-sponsored PCOS Consensus Workshop Group, 2004. World Health...

Introducción: Thyroid nodule is a very frequent pathology that affects 4-8% of population. Fine-needle aspiration (FNA) guided by ultrasound (US) is considered the gold standard test in diagnostic evaluation of thyroid nodules. This technique is being assumed more and more frequently by endocrinologists.Description of Methods: We conducted a retrospective study that included all thyroid US-guided FNA performed in 2014. We considered the following va...

Introduction: Our objective is to determine the profile of patients with differentiated thyroid cancer (DTC) attended in our center and the therapeutic approach employed.Methods: Retrospective review of medical records from patients treated for DTC during the years 2013 and 2014.Results: Data from 387 patients, 84% female, 96% Caucasian, mean follow up of 10.82 years. The average age at diagnosis was 44.24 years, 77% had normal thy...

Introduction: Roux-en-Y gastric bypass (RYGB) places patients at an increased risk of hypocalcemia due to the reduction in calcium absorption (because the procedure bypasses the duodenum and jejunum) and vitamin D deficiency. Subsequent thyroid surgery increases the risk of severe hypocalcemia due to potential post-operative hypoparathyroidism. Only a few cases have been published before of this kind of treatment-challenging hypocalcaemia.Case report: We...